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Deregulated expression of DP1 induces epidermal proliferation and enhances skin carcinogenesis.
Wang D, Russell J, Xu H, Johnson DG. Wang D, et al. Mol Carcinog. 2001 Jun;31(2):90-100. doi: 10.1002/mc.1044. Mol Carcinog. 2001. PMID: 11429786
In a two-stage chemical carcinogenesis assay, more and larger skin tumors developed in K5 DP1 transgenic mice than in nontransgenic mice. ...
In a two-stage chemical carcinogenesis assay, more and larger skin tumors developed in K5 DP1 transgenic mice than in nontransgenic m …
Tracing the cis-regulatory changes underlying the endometrial control of placental invasion.
Suhail Y, Maziarz JD, Novin A, Dighe A, Afzal J, Wagner G, Kshitiz. Suhail Y, et al. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2111256119. doi: 10.1073/pnas.2111256119. Proc Natl Acad Sci U S A. 2022. PMID: 35110402 Free PMC article.
Using an in vitro invasibility assay combined with CRISPR-Cas9 gene knockout, we found that the transcription factors GATA2 and TFDP1 strongly influence the invasibility of endometrial and skin fibroblasts. ...
Using an in vitro invasibility assay combined with CRISPR-Cas9 gene knockout, we found that the transcription factors GATA2 and TFDP1 …
Upregulation of E2F transcription factors in chemically induced mouse skin tumors.
Balasubramanian S, Ahmad N, Mukhtar H. Balasubramanian S, et al. Int J Oncol. 1999 Aug;15(2):387-90. doi: 10.3892/ijo.15.2.387. Int J Oncol. 1999. PMID: 10402252 Review.
To better understand the role of these transcription factors in epithelial tumorigenesis, we compared the expression of various proteins involved in the Rb/E2F pathway in epidermis and 7,12-dimethylbenz(a)anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate (TPA) …
To better understand the role of these transcription factors in epithelial tumorigenesis, we compared the expression of various proteins inv …
E2F as a regulator of keratinocyte proliferation: implications for skin tumor development.
Jones SJ, Dicker AJ, Dahler AL, Saunders NA. Jones SJ, et al. J Invest Dermatol. 1997 Aug;109(2):187-93. doi: 10.1111/1523-1747.ep12319308. J Invest Dermatol. 1997. PMID: 9242506 Free article.
Our results with the SCC25 cells and the E7-infected cells are consistent with the proposition that deregulated E2F expression/activity (in particular E2F1) may be involved in the unregulated proliferation of skin tumor cells....
Our results with the SCC25 cells and the E7-infected cells are consistent with the proposition that deregulated E2F expression/activity (in …